This product is an active protein and may elicit a biological response in vivo, handle with caution.
70 kDa zeta associated protein
70 kDa zeta-associated protein
Selective T cell defect
Syk related tyrosine kinase
Syk-related tyrosine kinase
Truncated ZAP kinase
Tyrosine protein kinase ZAP70
Tyrosine-protein kinase ZAP-70
Zeta chain associated protein kinase 70kD
Zeta chain associated protein kinase 70kDa
Zeta chain associated protein kinase 70kDa isoform 1
Zeta chain associated protein kinase 70kDa isoform 2
Zeta chain TCR associated protein kinase 70kD
Zeta chain TCR associated protein kinase 70kDa
FunctionPlays a role in T-cell development and lymphocyte activation. Essential for TCR-mediated IL-2 production. Isoform 1 induces TCR-mediated signal transduction, isoform 2 does not.
Tissue specificityExpressed in T- and natural killer cells.
Involvement in diseaseDefects in ZAP70 are the cause of selective T-cell defect (STD) [MIM:176947]. STD is an autosomal recessive form of severe combined immunodeficiency characterized by a selective absence of CD8-type T-cells.
Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily. Contains 1 protein kinase domain. Contains 2 SH2 domains.
DomainThe SH2 domains bind to the phosphorylated tyrosine-based activation motif (TAM) of CD3Z and the non-canonical phosphorylated tyrosine-based activation motif (TAM) of RHOH.
Post-translational modificationsPhosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation. Tyr-319 phosphorylation is essential for full activity.
Cellular localizationCytoplasm. Cell membrane. After antigen stimulation, isoform 1 concentrates at the immunological synapse and isoform 2 remains cytoplasmic. Co-localizes together with RHOH in the immunological synapse. RHOH is required for its proper localization to the cell membrane and cytoskeleton fractions in the thymocytes.