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Full length protein
Amino Acid Sequence
MGSSHHHHHHSSGLVPRGSHMGSMWERLNCAAEDFYSRLLQKFNEEKKGI RKDPFLYEADVQVQLISKGQPNPLKNILNENDIVFIVEKVPLEKEETSHI EELQSEETAISDFSTGENVGPLALPVGKARQLIGLYTMAHNPNMTHLKIN LPVTALPPLWVRCDSSDPEGTCWLGAELITTNNSITGIVLYVVSCKADKN YSVNLENLKNLHKKRHHLSTVTSKGFAQYELFKSSALDDTITASQTAIAL DISWSPVDEILQIPPLSSTATLNIKVESGEPRGPLNHLYRELKFLLVLAD GLRTGVTEWLEPLEAKSAVELVQEFLNDLNKLDGFGDSTKKDTEVETLKH DTAAVDRSVKRLFKVRSDLDFAEQLWCKMSSSVISYQDLVKCFTLIIQSL QRGDIQPWLHSGSNSLLSKLIHQSYHGTMDTVSLSGTIPVQMLLEIGLDK LKKDYISFFIGQELASLNHLEYFIAPSVDIQEQVYRVQKLHHILEILVSC MPFIKSQHELLFSLTQICIKYYKQNPLDEQHIFQLPVRPTAVKNLYQSEK PQKWRVEIYSGQKKIKTVWQLSDSSPIDHLNFHKPDFSELTLNGSLEERI FFTNMVTCSQVHFK
70 kDa including tags
1 to 591
His tag N-Terminus
Additional sequence information
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Constituents: 0.32% Tris HCl, 0.58% Sodium chloride, 20% Glycerol, 0.02% DTT
homolog of Drosophila Zwilch
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131).
Belongs to the ZWILCH family.
Chromosome, centromere, kinetochore.
Information by UniProt
SDS-PAGE - Human ZWILCH full length protein (ab181888)
15% SDS-PAGE analysis of 3ug ab181888.
has not yet been referenced specifically in any publications.
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