Recombinant Leiurus quinquestriatus Chlorotoxin protein (ab60871)

Overview

  • Product name
    Recombinant Leiurus quinquestriatus Chlorotoxin protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Leiurus quinquestriatus
    • Sequence
      Met-Cys-Met-Pro-Cys-Phe-Thr-Thr-Asp-His-Gln-Met-Al a-Arg-Lys-Cys-Asp-Asp-Cys-Cys-Gly-Gly-Lys-Gly-Arg- Gly-Lys-Cys-Tyr-Gly-Pro-Gln-Cys-Leu-Cys-Arg

Specifications

Our Abpromise guarantee covers the use of ab60871 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.

  • Reconstitution
    Reconstitute the contents of the vial in 0.1ml water.

General Info

  • Alternative names
    • CTX
  • Relevance
    Chlorotoxin is a chloride channel ligand from the venom of the Egyptian/North African/Israeli scorpion. It blocks small-conductance chloride channels. Glioma cells have recently been shown to express a glioma-specific chloride ion channel (GCC) that is sensitive to chlorotoxin (CTX). Chlorotoxin does not bind to normal brain parenchyma or endothelial cells but specifically binds to tumescent glial cells. Chlorotoxin is currently (2007) under phase II clinical trials, under the name TM-601 (a synthetic version of chlorotoxin); It crosses blood-brain and tissue barriers and binds to malignant brain tumor cells without affecting healthy tissue.

References

ab60871 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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