ReconstitutionReconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.
C-C motif chemokine 2
Chemokine (C C motif) ligand 2
Monocyte chemoattractant protein 1
Monocyte chemotactic and activating factor
Monocyte chemotactic protein 1
Monocyte secretory protein JE
Small inducible cytokine A2
Small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig je)
Small inducible cytokine subfamily A (Cys Cys), member 2
Small-inducible cytokine A2
FunctionChemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
Sequence similaritiesBelongs to the intercrine beta (chemokine CC) family.
Post-translational modificationsProcessing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant.