The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Endotoxin level< 0.100 Eu/µg
Additional notesThe biological activity of this product is determined by its ability to chemoattract total murine T cell population using a concentration range of 10.0-100.0 ng/ml.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionReconstitute with 20µl pure water.
C C motif chemokine 22
CC chemokine STCP 1
CC chemokine STCP-1
Chemokine (C C motif) ligand 22
Small inducible cytokine subfamily A (Cys Cys) member 22
Small-inducible cytokine A22
Stimulated T cell chemotactic protein 1
Stimulated T-cell chemotactic protein 1
FunctionMay play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.
Tissue specificityHighly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis.
Sequence similaritiesBelongs to the intercrine beta (chemokine CC) family.
Post-translational modificationsThe N-terminal processed forms MDC(3-69), MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes.