Serine (or cysteine) proteinase inhibitor, clade F (alpha 2 antiplasmin pigment epithelium derived factor) member 2
Serine (Or cysteine) proteinase inhibitor, clade F, member 2
Serine or cysteine peptidase inhibitor clade F member 2
Serpin peptidase inhibitor clade F
Serpin peptidase inhibitor, clade F (alpha 2 antiplasmin pigment epithelium derived factor) member 2
FunctionSerine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin.
Tissue specificityExpressed by the liver and secreted in plasma.
Involvement in diseaseDefects in SERPINF2 are the cause of alpha-2-plasmin inhibitor deficiency (APLID) [MIM:262850]. APLID is an autosomal recessive disorder resulting in severe hemorrhagic diathesis.
Sequence similaritiesBelongs to the serpin family.