The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityBlocks the binding of Mouse BAFF and Human APRIL to their receptors BCMA and TACI.
Endotoxin level< 0.100 Eu/µg
Additional notesPBS containing at least 0.1 % BSA should be used for further dilutions. Binds Mouse and Human BAFF and APRIL.
Blocks the binding of Mouse BAFF and Human APRIL to their receptors BCMA and TACI.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.
Constituent: 99% PBS
ReconstitutionReconstitute with 50 µl sterile water.
B cell maturation antigen
B cell maturation factor
B cell maturation protein
B-cell maturation protein
Tumor necrosis factor receptor superfamily member 17
FunctionReceptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
Tissue specificityExpressed in mature B-cells, but not in T-cells or monocytes.
Involvement in diseaseNote=A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.