Overview

Description

  • Nature
    Recombinant
  • Source
    HEK 293 cells
  • Amino Acid Sequence
    • Accession
    • Species
      Mouse
    • Molecular weight
      35 kDa
    • Amino acids
      1 to 46

Specifications

Our Abpromise guarantee covers the use of ab109162 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Blocks the binding of Mouse BAFF and Human APRIL to their receptors BCMA and TACI.
  • Applications

    Functional Studies

    SDS-PAGE

  • Endotoxin level
    < 0.100 Eu/µg
  • Purity
    > 95 % SDS-PAGE.

  • Form
    Lyophilised
  • Additional notes
    PBS containing at least 0.1 % BSA should be used for further dilutions. Binds Mouse and Human BAFF and APRIL. Blocks the binding of Mouse BAFF and Human APRIL to their receptors BCMA and TACI.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.

    Constituent: 99% PBS

  • Reconstitution
    Reconstitute with 50 µl sterile water.

General Info

  • Alternative names
    • B cell maturation antigen
    • B cell maturation factor
    • B cell maturation protein
    • B-cell maturation protein
    • BCM
    • BCMA
    • CD269
    • CD269 antigen
    • TNFRSF17
    • TNR17_HUMAN
    • Tumor necrosis factor receptor superfamily member 17
    see all
  • Function
    Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
  • Tissue specificity
    Expressed in mature B-cells, but not in T-cells or monocytes.
  • Involvement in disease
    Note=A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.
  • Sequence similarities
    Contains 1 TNFR-Cys repeat.
  • Cellular localization
    Cell membrane. Endomembrane system. Perinuclear Golgi-like structures.
  • Information by UniProt

References

ab109162 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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