Recombinant mouse beta Defensin 3 protein (ab125742)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionQ9WTL0
    • SpeciesMouse
    • SequenceKKINNPVSCL RKGGRCWNRC IGNTRQIGSC GVPFLKCCKR K
    • Molecular weight5 kDa
    • Amino acids23 to 63

Specifications

Our Abpromise guarantee covers the use of ab125742 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityMeasured by its antimicrobial activity against E. coli. The ED50 for this effect is typically 4-20µg/ml.
  • Applications

    Functional Studies

    SDS-PAGE

    HPLC

  • Purity> 98 % SDS-PAGE.
    ab125742 is purified by proprietary chromatographic techniques. Purity is greater than 98.0% as determined by RP-HPLC and SDS-PAGE.
  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Store under Desiccating conditions.

    pH: 7.40
    Constituent: 99% PBS

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • ReconstitutionIt is recommended to reconstitute the ab125742 in sterile ultra pure water not less than 100µg/ml, which can then be further diluted to other aqueous solutions. Upon reconstitution ab125742 should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles.

General Info

  • Alternative names
    • BD 3
    • BD-3
    • BD3
    • beta 103
    • Beta defensin 103A
    • Beta defensin 103A precursor
    • Beta defensin 3
    • Beta-defensin 103
    • Beta-defensin 3
    • D103A_HUMAN
    • DEF B3
    • DEFB 103
    • DEFB 103A
    • DEFB 3
    • DEFB-3
    • DEFB103
    • DEFB103A
    • DEFB103B
    • DEFB3
    • Defensin
    • Defensin beta 103A
    • Defensin beta 3
    • Defensin like protein
    • Defensin-like protein
    • HBD 3
    • hBD-3
    • HBD3
    • HBP 3
    • HBP3
    • mBD3
    see all
  • FunctionExhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistent E.faecium. No significant hemolytic activity was observed.
  • Tissue specificityHighly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. Low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine.
  • Sequence similaritiesBelongs to the beta-defensin family.
  • Cellular localizationSecreted.
  • Information by UniProt

References for Recombinant mouse beta Defensin 3 protein (ab125742)

ab125742 has not yet been referenced specifically in any publications.

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