Overview

Description

  • Nature
    Recombinant
  • Source
    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Accession
    • Species
      Mouse
    • Sequence
      MDRGVLPLPITLLFVIYSFVPTTGLAERVGCDLQPVDPTRGEVTFTTSQV SEGCVAQAANAVREVHVLFLDFP GMLSHLELTLQASKQNGTETQEVFL VLVSNKNVFVKFQAPEIPLHLAYDSSLVIFQGQPRVNITVLPSLTSRK QILDWAATKGAITSIAALDDPQSIVLQLGQDPKAPFLCLPEAHKDMGATL EWQPRAQTPVQSCRLEGVSGHK EAYILRILPGSEAGPRTVTVMMELSC TSGDAILILHGPPYVSWFIDINHSMQILTTGEYSVKIFPGSKVKGVELP DTPQGLIAEARKLNASIVTSFVELPLVSNVSLRASSCGGVFQTTPAPVV TTPPKDTCSPVLLMSLIQPKCGNQ VMTLALNKKHVQTLQCTITGLTFW DSSCQAEDTDDHLVLSSAYSSCGMKVTAHVVSNEVIISFPSGSPPLRK KVQCIDMDSLSFQLGLYLSPHFLQASNTIELGQQAFVQVSVSPLTSEVTV QLDSCHLDLGPEGDMVELIQSRT AKGSCVTLLSPSPEGDPRFSFLLRV YMVPTPTAGTLSCNLALRPSTLSQEVYKTVSMRLNIVSPDLS
    • Molecular weight
      61 kDa
    • Amino acids
      28 to 578
    • Tags
      His tag C-Terminus

Specifications

Our Abpromise guarantee covers the use of ab123754 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    HPLC

    SDS-PAGE

  • Purity
    > 95 % SDS-PAGE.
    ab123754 is purified by proprietary chromatographic techniques. Purity is greater than 95% as determined by HPLC and SDS-PAGE.
  • Form
    Lyophilised
  • Additional notes
    Centrifuge the vial prior to opening.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

  • Reconstitution
    Centrifuge the vial prior to opening. Reconstitute in sterile PBS to a concentration of 100 µg/ml. This solution can then be diluted into other aqueous buffers. Reconstituted ab123754 should be stored at 4°C for 2-7 days and at -20°C for future use. For long term storage it is recommended to add a carrier protein (0.1 % HSA or BSA). Avoid freeze/thaw cycles.

General Info

  • Alternative names
    • AI528660
    • AI662476
    • CD 105
    • CD105
    • CD105 antigen
    • EGLN_HUMAN
    • END
    • Endoglin
    • Eng
    • FLJ41744
    • HHT1
    • ORW
    • ORW1
    • Osler Rendu Weber syndrome 1
    • RP11 228B15.2
    • S-endoglin
    • SN6
    see all
  • Function
    Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.
  • Tissue specificity
    Endoglin is restricted to endothelial cells in all tissues except bone marrow.
  • Involvement in disease
    Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300, 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity.
  • Cellular localization
    Membrane.
  • Information by UniProt

References

ab123754 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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