Recombinant Mouse Cystatin C protein (ab63286)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Mouse
    • Sequence
      MRGSHHHHHH GMAS-ATPKQG PRMLGAPEEA DANEEGVRRA LDFAVSEYNK GSNDAYHSRA IQVVRARKQL VAGVNYFLDV EMGRTTCTKS QTNLTDCPFH DQPHLMRKAL CSFQIYSVPW KGTHSLTKFS CKNA

Specifications

Our Abpromise guarantee covers the use of ab63286 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

  • Purity
    > 95 % SDS-PAGE.
    Please filter the product by an appropriate sterile filter before using it in cell culture.
  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 50mM Sodium chloride, 20mM Tris, pH 7.5

  • Reconstitution
    Add deionized water to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely.

General Info

  • Alternative names
    • AD 8
    • AD8
    • Amyloid angiopathy and cerebral hemorrhage
    • ARMD11
    • bA218C14.4
    • bA218C14.4 (cystatin C)
    • Cst 3
    • Cst3
    • CST3 protein
    • Cystatin 3
    • Cystatin-3
    • Cystatin-C
    • Cystatin3
    • CystatinC
    • CYTC_HUMAN
    • Epididymis secretory protein Li 2
    • Gamma trace
    • Gamma-trace
    • HCCAA
    • HEL S 2
    • MGC117328
    • Neuroendocrine basic polypeptide
    • Post gamma globulin
    • Post-gamma-globulin
    see all
  • Function
    As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.
  • Tissue specificity
    Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in various body fluids, such as the cerebrospinal fluid and plasma. Expressed in highest levels in the epididymis, vas deferens, brain, thymus, and ovary and the lowest in the submandibular gland.
  • Involvement in disease
    Amyloidosis 6
    Macular degeneration, age-related, 11
  • Sequence similarities
    Belongs to the cystatin family.
  • Post-translational
    modifications
    The Thr-25 variant is O-glycosylated with a core 1 or possibly core 8 glycan. The signal peptide of the O-glycosylated Thr-25 variant is cleaved between Ala-20 and Val-21.
  • Cellular localization
    Secreted.
  • Information by UniProt

Images

  • LANE 1. M.W. marker - 14, 21, 31, 45, 66, 97 kDa. LANE 2. reduced and heated sample, 5µg/lane. LANE 3. non-reduced and non-heated sample,5µg/lane.

References

ab63286 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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