The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityInhibits adipogenesis of 3T3L-1 cells. Induces Sox-9 in 3T3L-1 cells.
Endotoxin level< 0.100 Eu/µg
% SDS-PAGE. ab108574 is 0.2µm filtered
Additional notesWorking aliquots are stable for up to 3 months when stored at -20°C.
Inhibits adipogenesis of 3T3L-1 cells. Induces Sox-9 in 3T3L-1 cells.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Adipocyte differentiation inhibitor protein
Delta like 1 homolog
Delta like homolog
Delta like protein
Fetal antigen 1
Preadipocyte factor 1
Protein delta homolog 1
FunctionMay have a role in neuroendocrine differentiation.
Tissue specificityFound within the stromal cells in close contact to the vascular structure of placental villi, yolk sac, fetal liver, adrenal cortex and pancreas and in the beta cells of the islets of Langerhans in the adult pancreas. Found also in some forms of neuroendocrine lung tumor tissue.
Sequence similaritiesContains 6 EGF-like domains.
Post-translational modificationsN- and O-glycosylated.
Recombinant Mouse DLK protein (Fc fragment) images
Functional Studies - Mouse DLK protein fragment:Fc portion of human IgG (ab108574)
Induction of SOX-9 with the treatment of recombinant mouse DLK-Fc (ab108574). A mouse preadpipocyte cell line, 3T3L1, was stimulated with 5µg/ml of ab108574 as in indicated time points and each cell lysate was prepared and subjected to western blot by using anti-rabbit Sox-9 and anti-rabbit GAPDH.