The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Endotoxin level< 0.100 Eu/µg
Additional notesPBS containing at least 0.1% BSA should be used for further dilutions.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C.
ReconstitutionReconstitute with 50 µl sterile water.
Death receptor 6
TNFR related death receptor 6
Tumor necrosis factor receptor superfamily member 21
Tumor necrosis factor receptor superfamily member 21 precursor
FunctionMay activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
Tissue specificityHighly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.
Sequence similaritiesContains 1 death domain. Contains 4 TNFR-Cys repeats.