The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityThe ED50 as determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells is < 0.05 ng/ml, corresponding to a specific activity of > 2 x 107 units/mg.
% SDS-PAGE. Purity is greater than 98% as determined by HPLC and SDS-PAGE. Endotoxin Level: <0.1 ng/µg.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C. Store under Desiccating conditions.
pH: 4.00 Constituent: 0.13% Sodium citrate
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionReconstitute in H2O to a concentration of 0.1-1 mg/ml. The solution can then be diluted into other aqueous buffers and store at 4°C for 1 week or –20°C for future use. Reconstituted ab123845 should be
stored at working aliquots at -20°C.
Colony stimulating factor 3
Colony stimulating factor 3 (granulocyte)
Granulocyte colony stimulating factor
Granulocyte colony-stimulating factor
Macrophage granulocyte inducer 2
FunctionGranulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.
Sequence similaritiesBelongs to the IL-6 superfamily.
Post-translational modificationsO-glycan consists of Gal-GalNAc disaccharide which can be modified with up to two sialic acid residues (done in recombinantly expressed G-CSF from CHO cells).