Recombinant mouse IL1 alpha protein (ab119727)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionP01582
    • SpeciesMouse
    • Molecular weight18 kDa
    • Amino acids115 to 270

Associated products

Specifications

Our Abpromise guarantee covers the use of ab119727 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityThe ED50 as determined by the dose-dependent stimulation of the proliferation of murine D10S cells was found to be < 0.01ng/ml, corresponding to a specific activity of 1 x 108 IU/mg.
  • Applications

    HPLC

    SDS-PAGE

    Functional Studies

  • Purity> 98 % SDS-PAGE.
    Purity: > 98% by SDS-PAGE and HPLC analysis. Endotoxin level is <0.1 ng per µg of IL1 alpha.
  • FormLyophilised
  • Additional notesab119727 is best-stored desiccated.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -80°C. Avoid freeze / thaw cycle. For long term storage it is recommended to add a carrier protein on reconstitution (0.1% HSA or BSA).

    Constituent: 99% PBS

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • ReconstitutionCentrifuge the vial prior to opening. Reconstitute in water to a concentration of not less than 100 µg/ml. which can then be diluted into other aqueous solutions.

General Info

  • Alternative names
    • BAF
    • FAF
    • Hematopoietin 1
    • Hematopoietin-1
    • IL 1 alpha
    • IL 1A
    • IL-1 alpha
    • Il-1a
    • IL1
    • IL1 ALPHA
    • IL1A
    • IL1A_HUMAN
    • IL1F1
    • Interleukin 1 alpha
    • Interleukin-1 alpha
    • Interleukin1 alpha
    • LAF
    • LEM
    • Preinterleukin 1 alpha
    • Pro interleukin 1 alpha
    see all
  • FunctionProduced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
  • Sequence similaritiesBelongs to the IL-1 family.
  • DomainThe similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
  • Cellular localizationSecreted. The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
  • Information by UniProt

References for Recombinant mouse IL1 alpha protein (ab119727)

ab119727 has not yet been referenced specifically in any publications.

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