SequenceInterleukin-10 (IL-10), originally known as Cytokine Synthesis Inhibitory factor (CSIF), is an 18.7 kDa protein of 160 amino acid residues that shares over 80% sequence homology with the Epstein-Barr Virus protein BCRFI.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Endotoxin level< 0.100 Eu/µg
Additional notesThe ED50, determined by the dose-dependent co-stimulation (with IL-4) of the proliferation of murine MC/9 cells, is < 2.0 ng/ml, corresponding to a specific activity of > 5 x 105 units/mg.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionReconstitute in water to a concentration of 0.1-1.0 mg/ml. Note: Allow the reconstituted vial to sit at room temperature for 1 hour before use.
Cytokine synthesis inhibitory factor
T-cell growth inhibitory factor
FunctionInhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.
Tissue specificityProduced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types.