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Full length protein
Amino Acid Sequence
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ab119723 is capable of inhibiting IL1 alpha activity in helper T cell line D10.G4.1.
ab119723 was purified by proprietary chromatographic techniques and Gel Filtration.
Purity: > 98 % by SDS-PAGE
Concentration information loading...
Stability and Storage
Shipped at 4°C. Store at -80°C. Avoid freeze / thaw cycle. For long term storage it is recommended to add a carrier protein on reconstitution (0.1% HSA or BSA).
Constituent: 0.02% Sodium carbonate
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Centrifuge the vial prior to opening. Reconstitute in sterile ddH2O to a concentration = 100 µg/ml. This solution can then be diluted into other aqueous buffers.
Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.
The intracellular form of IL1RN is predominantly expressed in epithelial cells.
Involvement in disease
Microvascular complications of diabetes 4
Interleukin 1 receptor antagonist deficiency
Cytoplasm and Secreted.
Information by UniProt
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"