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Source Escherichia coli
Amino Acid Sequence
Sequence The sequence of the first six N-terminal amino acids was determined and was found to be Ala-Cys-Arg-Pro-Ser-Gly.
Molecular weight 17 kDa
Amino acids 25 to 178 Specifications
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activity ab119723 is capable of inhibiting IL1 alpha activity in helper T cell line D10.G4.1.
Purity > 98
% SDS-PAGE. ab119723 was purified by proprietary chromatographic techniques and Gel Filtration.
Purity: > 98 % by SDS-PAGE
Concentration information loading... Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -80°C. Avoid freeze / thaw cycle. For long term storage it is recommended to add a carrier protein on reconstitution (0.1% HSA or BSA).
Constituent: 0.02% Sodium carbonate
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Reconstitution Centrifuge the vial prior to opening. Reconstitute in sterile ddH2O to a concentration = 100 µg/ml. This solution can then be diluted into other aqueous buffers.
Function Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.
Tissue specificity The intracellular form of IL1RN is predominantly expressed in epithelial cells.
Involvement in disease Microvascular complications of diabetes 4 Interleukin 1 receptor antagonist deficiency
Cellular localization Cytoplasm and Secreted.
Information by UniProt
References for Recombinant mouse IL1RA protein (ab119723)
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"