The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityThe ED50 range is 0.1-0.4 ng/ml, as determined by the dose-dependent stimulation of the proliferation of murine CTLL-2 cells.
% SDS-PAGE. Purity: >98% by SDS-PAGE and HPLC analysis.
Endotoxin level is <0.1 ng per µg of IL2.
Additional notesab119728 is best-stored desiccated.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -80°C. Avoid freeze / thaw cycle. For long term storage it is recommended to add a carrier protein on reconstitution (0.1% HSA or BSA).
pH: 4.00 Constituent: 0.26% Sodium citrate
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionCentrifuge the vial prior to opening. Reconstitute in 100 mM AcOH to a concentration of 0.1-1 µg/µl to regain full activity. The solution can then be diluted into other aqueous buffers.
Involved in regulation of T cell clonal expansion
T Cell Growth Factor
T-cell growth factor
FunctionProduced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Involvement in diseaseNote=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.