Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionP04351
    • SpeciesMouse
    • Molecular weight17 kDa
    • Amino acids21 to 169

Specifications

Our Abpromise guarantee covers the use of ab119728 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityThe ED50 range is 0.1-0.4 ng/ml, as determined by the dose-dependent stimulation of the proliferation of murine CTLL-2 cells.
  • Applications

    SDS-PAGE

    HPLC

    Functional Studies

  • Purity> 98 % SDS-PAGE.
    Purity: >98% by SDS-PAGE and HPLC analysis. Endotoxin level is <0.1 ng per µg of IL2.
  • FormLyophilised
  • Additional notesab119728 is best-stored desiccated.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -80°C. Avoid freeze / thaw cycle. For long term storage it is recommended to add a carrier protein on reconstitution (0.1% HSA or BSA).

    pH: 4.00
    Constituent: 0.26% Sodium citrate

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • ReconstitutionCentrifuge the vial prior to opening. Reconstitute in 100 mM AcOH to a concentration of 0.1-1 µg/µl to regain full activity. The solution can then be diluted into other aqueous buffers.

General Info

  • Alternative names
    • Aldesleukin
    • IL 2
    • IL-2
    • IL2
    • IL2_HUMAN
    • Interleukin 2
    • Interleukin-2
    • Involved in regulation of T cell clonal expansion
    • Lymphokine
    • OTTHUMP00000164090
    • POIL2
    • T Cell Growth Factor
    • T-cell growth factor
    • TCGF
    see all
  • FunctionProduced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
  • Involvement in diseaseNote=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
  • Sequence similaritiesBelongs to the IL-2 family.
  • Cellular localizationSecreted.
  • Information by UniProt

References for Recombinant mouse IL2 protein (ab119728)

ab119728 has not yet been referenced specifically in any publications.

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