The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ED50 < 5 ng/ml as determined in a cell proliferation assay using CTLL-2 mouse cytotoxic T cells (Gearing and Bird (1987) Production and assay of IL2. In Lymphokines and Interferons: A Practical Approach (Clemens et al. eds.) pp. 291-301). The ED50 for this effect is typically < 1.0 ng/ml.
% SDS-PAGE. ab183262 is purified by chromatography, then sterile filtered.
Extinction coefficient: 0.9
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot. Store at -80°C.
Constituents: 99% PBS, 0.1% BSA
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Add 0.025 ml distilled water.
Involved in regulation of T cell clonal expansion
T Cell Growth Factor
T-cell growth factor
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Involvement in disease
Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.