The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. > 95% by SDS-PAGE and RP-HPLC analysis
Endotoxin level is < 0.01 ng per µg of IL21.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -80°C. Avoid freeze / thaw cycle. For long term storage it is recommended to add a carrier protein on reconstitution (0.1% HSA or BSA).
pH: 8.50 Constituent: 0.17% Sodium bicarbonate
ReconstitutionIt is recommended to reconstitute the lyophilized product with sterile water to a concentration of 0.1 mg/ml, which can be further diluted into other aqueous solutions.
FunctionCytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
Tissue specificityExpressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.
Sequence similaritiesBelongs to the IL-15/IL-21 family.