Recombinant Mouse Jagged1 protein (ab109346)

Overview

Description

  • NatureRecombinant
  • SourceHEK 293 cells
  • Amino Acid Sequence
    • AccessionQ9QXX0
    • SpeciesMouse
    • Molecular weight150 kDa
    • Amino acids1 to 1067

Specifications

Our Abpromise guarantee covers the use of ab109346 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Inhibition Assay

  • Endotoxin level< 0.100 Eu/µg
  • Purity> 90 % SDS-PAGE.
    ab109346 is an 0.2 µm filtered solution.
  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Constituent: PBS

  • ReconstitutionFor 10µg size: reconstitute with 100µl sterile water. For 50µg size: reconstitute with 50µl sterile water

General Info

  • Alternative names
    • AGS
    • AHD
    • AWS
    • CD 339
    • CD339
    • CD339 antigen
    • Headturner
    • hJ1
    • Htu
    • Jag 1
    • Jag1
    • JAG1_HUMAN
    • Jagged 1
    • Jagged1
    • Jagged1 (Alagille syndrome)
    • JAGL1
    • MGC104644
    • OTTHUMP00000030278
    • Protein jagged-1
    • Ser 1
    • Ser1
    • Serrate 1
    • Slalom
    see all
  • FunctionLigand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).
  • Tissue specificityWidely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.
  • Involvement in diseaseDefects in JAG1 are the cause of Alagille syndrome type 1 (ALGS1) [MIM:118450]. Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems.
    Defects in JAG1 are a cause of tetralogy of Fallot (TOF) [MIM:187500]. TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation. Surgical correction is emergent.
  • Sequence similaritiesContains 1 DSL domain.
    Contains 15 EGF-like domains.
  • Developmental stageExpressed in 32-52 days embryos in the distal cardiac outflow tract and pulmonary artery, major arteries, portal vein, optic vesicle, otocyst, branchial arches, metanephros, pancreas, mesocardium, around the major bronchial branches, and in the neural tube.
  • Cellular localizationMembrane.
  • Information by UniProt

References for Recombinant Mouse Jagged1 protein (ab109346)

ab109346 has not yet been referenced specifically in any publications.

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