Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesMouse
    • SequenceMRLHQRLGDI VAHLPDGGKG SWEKLIQDQR SHQANPAAHL TGANASLIGI GGPLLWETRL GLAFLRGLTY HDGALVTMEP GYYYVYSKVQ LSGVGCPQGL ANGLPITHGL YKRTSRYPKE LELLVSRRSP CGRANSSRVW WDSSFLGGVV HLEAGEEVVV RVPGNRLVRP RDGTRSYFGA FMV

Specifications

Our Abpromise guarantee covers the use of ab50095 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Endotoxin level< 0.100 Eu/µg
  • Purity> 95 % SDS-PAGE.
    Greater than 98% by SDS-PAGE and HPLC analyses.
  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Endotoxin level is less than 0.1 ng per µg (1EU/µg).

  • ReconstitutionCentrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4oC for 1 week or -20oC for future use.

General Info

  • Alternative names
    • CD 258
    • CD258
    • CD258 antigen
    • Delta transmembrane LIGHT
    • Herpes virus entry mediator ligand
    • Herpesvirus entry mediator A
    • Herpesvirus entry mediator ligand
    • herpesvirus entry mediator-ligand
    • HVEM L
    • HVEM-L
    • HVEML
    • Ligand for herpesvirus entry mediator
    • LIGHT
    • LTg
    • soluble form
    • TNF14
    • TNF14_HUMAN
    • TNFSF 14
    • Tnfsf14
    • TNFSF14 protein
    • TR 2
    • TR2
    • Tumor necrosis factor (ligand) superfamily, member 14
    • Tumor necrosis factor ligand superfamily member 14
    • Tumor necrosis factor ligand superfamily, member 14
    • Tumor necrosis factor receptor like 2
    • tumor necrosis factor receptor-like 2
    • Tumor necrosis factor superfamily member 14
    • Tumor necrosis factor superfamily member LIGHT
    see all
  • FunctionCytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
  • Tissue specificityPredominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines.
  • Sequence similaritiesBelongs to the tumor necrosis factor family.
  • Post-translational
    modifications
    N-glycosylated.
    The soluble form of isoform 1 derives from the membrane form by proteolytic processing.
  • Cellular localizationCytoplasm; Secreted and Cell membrane.
  • Information by UniProt

References for Recombinant Mouse LIGHT protein (ab50095)

ab50095 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"