Overview

Description

  • NatureRecombinant
  • SourceInsect cells
  • Amino Acid Sequence
    • AccessionQ8BHC0
    • SpeciesMouse
    • Amino acids24 to 228

Specifications

Our Abpromise guarantee covers the use of ab54342 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 95 % SDS-PAGE.

  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C. Avoid freeze / thaw cycle.

    Preservative: None
    Buffer: None
    Endotoxin level: < 0.1 ng per µg LYVE1.

  • ReconstitutionThis protein is soluble in water and most aqueous buffers. It should be reconstituted in PBS or medium to a concentration not lower than 50 µg/ml.

General Info

  • Alternative names
    • Cell surface retention sequence-binding protein 1
    • CRSBP 1
    • CRSBP-1
    • CRSBP1
    • extracellular link domain containing 1
    • extracellular link domain-containing 1
    • Extracellular link domain-containing protein 1
    • HAR
    • Hyaluronic acid receptor
    • Lymphatic endothelium specific hyaluronan receptor
    • lymphatic vessel endothelial hyaluronan receptor 1
    • Lymphatic vessel endothelial hyaluronic acid receptor 1
    • LYVE 1
    • LYVE-1
    • LYVE1
    • LYVE1_HUMAN
    • XLKD1
    see all
  • FunctionLigand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
  • Tissue specificityMainly expressed in endothelial cells lining lymphatic vessels.
  • Sequence similaritiesContains 1 Link domain.
  • Post-translational
    modifications
    O-glycosylated.
  • Cellular localizationMembrane. Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface.
  • Information by UniProt

References for Recombinant Mouse LYVE1 protein (ab54342)

ab54342 has not yet been referenced specifically in any publications.

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