The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityDefined by its ability to chemoattract Human neutrophils using a concentration range of 0.1-10 ng/ml, corresponding to a Specific Activity of 10,000-100,000IU/mg.
% SDS-PAGE. ab125731 is purified by proprietary chromatographic techniques. Purity is greater than 97.0% as determined by RP-HPLC and SDS-PAGE.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C. Store under desiccating conditions.
pH: 7.40 Constituent: 99% PBS
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionIt is recommended to reconstitute ab125731 in sterile ultra pure water not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Upon reconstitution ab125731 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Chemokine CC motif ligand 9
Macrophage inflammatory protein 1-gamma
Macrophage inflammatory protein-related protein 2
Small inducible cytokine A9
Small-inducible cytokine A9
FunctionMonokine with inflammatory, pyrogenic and chemokinetic properties. Circulates at high concentrations in the blood of healthy animals. Binding to a high-affinity receptor activates calcium release in neutrophils. It also inhibits colony formation of bone marrow myeloid immature progenitors.
Tissue specificityExpressed mainly in the liver, lung, and the thymus, although some expression has been detected in a wide variety of tissues except brain.
Sequence similaritiesBelongs to the intercrine beta (chemokine CC) family.