The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Endotoxin level< 0.100 Eu/µg
Additional notesThe biological activity of murine MCP-5 was determined by a chemotaxis assay using human peripheral blood monocytes. Significant chemotaxis was achieved using a concentration of 50 ng/ml.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
C-C motif chemokine 12
Macrophage/monocyte Chemotactic Protein
Monocyte chemoattractant protein 5
Monocyte chemotactic protein 5
Small inducible cytokine A12
Small-inducible cytokine A12
FunctionChemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation.
Tissue specificityPredominantly expressed in the lymph nodes and thymus. Also found in the salivary glands containing lymph nodes, breast, heart, lung, brain, small intestine, kidney and colon.
Sequence similaritiesBelongs to the intercrine beta (chemokine CC) family.