The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. >98% by SDS-PAGE and HPLC analyses.
Additional notesThe reconstituted solution can be diluted into other buffers and stored at 4°C for 1 week or –20°C for future use.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: 5mM Tris, 100mM Sodium chloride, pH 8.0
Endotoxin level is <0.1 ng per µg of MCSF.
ReconstitutionCentrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml.
Colony stimulating factor 1
Colony stimulating factor 1 (macrophage)
Colony stimulating factor macrophage specific
Macrophage colony stimulating factor
Macrophage Colony Stimulating Factor 1
Processed macrophage colony-stimulating factor 1
FunctionGranulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. CSF-1 induces cells of the monocyte/macrophage lineage. It plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy.
Post-translational modificationsGlycosylation and proteolytic cleavage yield different soluble forms. A high molecular weight soluble form is a proteoglycan containing chondroitin sulfate. Isoform 1 is N- and O-glycosylated. Isoform 3 is N-glycosylated.
Cellular localizationCell membrane and Secreted > extracellular space.