This product is an active protein and may elicit a biological response in vivo, handle with caution.
90 kDa ribosomal protein S6 kinase 4
Mitogen and stress activated protein kinase 2
Nuclear mitogen and stress activated protein kinase 2
Nuclear mitogen- and stress-activated protein kinase 2
Ribosomal protein kinase B
Ribosomal protein S6 kinase 90kD polypeptide 4
Ribosomal protein S6 kinase 90kDa polypeptide 4
Ribosomal protein S6 kinase alpha 4
Ribosomal protein S6 kinase alpha-4
FunctionSerine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB. Essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF) and result in the transcriptional activation of several immediate early genes, including proto-oncogenes FOS and JUN (By similarity). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).
Sequence similaritiesBelongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 2 protein kinase domains.