Recombinant mouse MSK2 / RSK-B protein (ab125610)

Overview

  • Product name
    Recombinant mouse MSK2 / RSK-B protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Accession
    • Species
      Mouse
    • Molecular weight
      114 kDa including tags
    • Amino acids
      1 to 773

Associated products

Specifications

Our Abpromise guarantee covers the use of ab125610 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Specific activity: 9 nmol/mg/min.
  • Applications

    Western blot

    Functional Studies

    SDS-PAGE

  • Form
    Liquid
  • Additional notes

    ab204879 (RPS6 peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.005% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • 90 kDa ribosomal protein S6 kinase 4
    • EC 2.7.11.1
    • KS6A4_HUMAN
    • Mitogen and stress activated protein kinase 2
    • Nuclear mitogen and stress activated protein kinase 2
    • Nuclear mitogen- and stress-activated protein kinase 2
    • Ribosomal protein kinase B
    • Ribosomal protein S6 kinase 90kD polypeptide 4
    • Ribosomal protein S6 kinase 90kDa polypeptide 4
    • Ribosomal protein S6 kinase alpha 4
    • Ribosomal protein S6 kinase alpha-4
    • RPS6KA4
    • RSKB
    • S6K-alpha-4
    see all
  • Function
    Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB. Essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF) and result in the transcriptional activation of several immediate early genes, including proto-oncogenes FOS and JUN (By similarity). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).
  • Sequence similarities
    Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 2 protein kinase domains.
  • Cellular localization
    Nucleus.
  • Information by UniProt

Images

  • The specific activity of ab125610 was determined to be 9 nmol/mg/min by Kinase Assay.
  • SDS-PAGE analysis of ab125610.

References

ab125610 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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