The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityab123841 is fully biologically active when compared to standards. The ED50 is measured by the dose-dependent induction of Human TF-1 cell proliferation is typically 0.1–1 ng/ml.
% SDS-PAGE. Purity is greater than 98% as determined by HPLC and SDS-PAGE. Endotoxin Level:<0.1 ng/µg.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionReconstitute in water to a concentration of 0.1-1.0 mg/ml containing 1% HSA or BSA. The solution can be diluted into other aqueous buffers and stored at 4°C for 2-7 days or store at –20°C for future use. For long-term storage, it is recommended to add a carrier protein (0.1% HAS or BSA). Avoid freeze/thaw cycles.
Beta nerve growth factor
Beta-nerve growth factor
Nerve growth factor beta
Nerve growth factor beta polypeptide
Nerve growth factor beta subunit
FunctionNerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).
Involvement in diseaseNeuropathy, hereditary sensory and autonomic, 5
Sequence similaritiesBelongs to the NGF-beta family.