ReconstitutionReconstitute with 100 ul sterile deionized water. For long term storage or for preparation of more diluted working stock solution, a carrier protein (e.g. 1% serum albumin) should be added to the vial.
Linker for activation of B cells
Linker for activation of B-cells
Linker for activation of T cells family member 2
Linker for activation of T cells transmembrane adaptor 2
Linker for activation of T-cells family member 2
Membrane associated adapter molecule
Membrane-associated adapter molecule
Non T cell activation linker
Non-T-cell activation linker
Williams Beuren syndrome chromosome region 15
Williams Beuren syndrome chromosome region 5
Williams-Beuren syndrome chromosomal region 15 protein
Williams-Beuren syndrome chromosomal region 5 protein
FunctionInvolved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
Tissue specificityHighly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).
Involvement in diseaseNote=LAT2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of LAT2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
Post-translational modificationsPhosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2. May be polyubiquitinated.
Cellular localizationCell membrane. Present in lipid rafts.
SDS Page analysis of ab56522: 12% separating gel, 6% stacking gel; reducing conditions. Staining with Coomasie Blue.
Lane 1 to 4: mouse NTAL recombinant protein: 2 µg, 1 µg, 0.5 µg, 0.2 µg per lane).
Western blot - NTAL protein (His tag) (ab56522)
WB analysis of ab56522: 12% separating gel, 6% stacking gel; reducing conditions. Immunostaining with NTAL specific antibody. Detection with Goat anti-mouse/ HRP secondary antibody.
Lane 1 to 4: Amount of mouse NTAL recombinant protein loaded on each lane: (1) 0.050 µg, (2) 0.020 µg, (3) 0.005 µg, (4) 0.001 µg.
References for Recombinant Mouse NTAL protein (ab56522)
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