The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Measured by its binding ability in a functional ELISA. Immobilized mouse PCSK9 at 10 µg/ml (100 µl/well) can bind biotinylated rhLDLR. The EC50 of biotinylated Human LDLR is 0.1 µg/ml.
< 1.000 Eu/µg
% SDS-PAGE. ab167759 is lyophilized from 0.22 µm filtered solution.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 7.40 Constituents: 94% PBS, 5% Trehalose
This product is an active protein and may elicit a biological response in vivo, handle with caution.
It is strongly recommended to reconstitute the protein with 1000 µl PBS, pH7.4 to a stock solution of 100 µg/ml. Solubilize for 30 to 60 minutes at room temperature with occasional gentle mixing. Carrier protein (0.1% HSA or BSA) is strongly recommended for further dilution and long term storage.
Convertase subtilisin/kexin type 9 preproprotein
Hypercholesterolemia autosomal dominant 3
Neural apoptosis regulated convertase 1
Neural apoptosis-regulated convertase 1
Proprotein convertase 9
Proprotein convertase PC9
Proprotein convertase subtilisin/kexin type 9
Subtilisin/kexin like protease PC9
Subtilisin/kexin-like protease PC9
May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis.
Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.
Involvement in disease
Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant.
Belongs to the peptidase S8 family. Contains 1 peptidase S8 domain.
The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme.