Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesMouse
    • SequenceMHHHHHHMKI EEGKLVIWIN GDKGYNGLAE VGKKFEKDTG IKVTVEHPDK LEEKFPQVAA TGDGPDIIFW AHDRFGGYAQ SGLLAEITPD KAFQDKLYPF TWDAVRYNGK LIAYPIAVEA LSLIYNKDLL PNPPKTWEEI PALDKELKAK GKSALMFNLQ EPYFTWPLIA ADGGYAFKYE NGKYDIKDVG VDNAGAKAGL TFLVDLIKNK HMNADTDYSI AEAAFNKGET AMTINGPWAW SNIDTSKVNY GVTVLPTFKG QPSKPFVGVL SAGINAASPN KELAKEFLEN YLLTDEGLEA VNKDKPLGAV ALKSYEEELA KDPRIAATME NAQKGEIMPN IPQMSAFWYA VRTAVINAAS GRQTVDEALK DAQTNSSSNN NNNNNNNNLG IEGRGSHMAA AEAANCIMEV SCGQAESSEK PNAEDMTSKD YYFDSYAHFG IHEEMLKDEV RTLTYRNSMF HNRHLFKDKV VLDVGSGTGI LCMFAAKAGA RKVIGIECSS ISDYAVKIVK ANKLDHVVTI IKGKVEEVEL PVEKVDIIIS EWMGYCLFYE SMLNTVLHAR DKWLAPDGLI FPDRATLYVT AIEDRQYKDY KIHWWENVYG FDMSCIKDVA IKEPLVDVVD PKQLVTNACL IKEVDIYTVK VEDLTFTSPF CLQVKRNDYV HALVAYFNIE FTRCHKRTGF STSPESPYTH WKQTVFYMED YLTVKTGEEI FGTIGMRPNA KNNRDLDFTI DLDFKGQLCE LSCSTDYRMR
    • Amino acids1 to 353

Specifications

Our Abpromise guarantee covers the use of ab78937 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activitySpecific Activity: 10,000 unit/ml. Unit Definition : One unit will transfer 1pmol of methyl group to synthetic peptide of histone H4 for 10 minutes at 37°C.
  • Applications

    SDS-PAGE

  • Purity> 90 % SDS-PAGE.
    Purified by using conventional chromatography techniques.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 40% Glycerol, 40mM Tris, 4mM Magnesium chloride, 2mM DTT, 100mM Sodium chloride, pH 8

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • ANM 1
    • ANM1
    • ANM1_HUMAN
    • HCP 1
    • HCP1
    • Heterogeneous nuclear ribonucleoprotein methyltransferase 1 like 2
    • Heterogeneous nuclear ribonucleoproteins methyltransferase like 2
    • Heterogeneous nuclear ribonucleoproteins methyltransferase like2
    • Histone-arginine N-methyltransferase PRMT1
    • HMT 2
    • HMT1 (hnRNP methyltransferase S. cerevisiae) like 2
    • HMT1 hnRNP methyltransferase
    • HMT1 hnRNP methyltransferase like 2
    • HMT1 hnRNP methyltransferase like 2 (S. cerevisiae)
    • HMT2
    • HRMT1 L2
    • HRMT1L 2
    • HRMT1L2
    • Human mRNA for suppressor for yeast mutant
    • Human mRNA for suppressor for yeast mutant complete cds
    • Interferon receptor 1 bound protein 4
    • Interferon receptor 1 bound protein4
    • Interferon receptor 1-bound protein 4
    • Interferon receptor 1bound protein 4
    • IR1 B4
    • IR1B 4
    • IR1B4
    • Mrmt 1
    • Mrmt1
    • PRMT 1
    • PRMT1
    • Protein arginine methyltransferase 1
    • Protein arginine N methyltransferase 1
    • Protein arginine N methyltransferase1
    • Protein arginine N-methyltransferase 1
    • R1B4
    • S. cerevisiae like 2
    see all
  • FunctionArginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway.
  • Tissue specificityWidely expressed.
  • Sequence similaritiesBelongs to the protein arginine N-methyltransferase family.
  • Cellular localizationNucleus. Cytoplasm > cytosol.
  • Information by UniProt

Recombinant mouse PRMT1 protein images

  • ab78937 on 15% SDS-PAGE, 3µg.

References for Recombinant mouse PRMT1 protein (ab78937)

ab78937 has not yet been referenced specifically in any publications.

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