Recombinant mouse Prorenin protein (ab123479)

Overview

Description

  • Nature
    Recombinant
  • Source
    HEK 293 cells
  • Amino Acid Sequence
    • Accession
    • Species
      Mouse
    • Molecular weight
      42 kDa including tags
    • Amino acids
      1 to 402
    • Tags
      His tag C-Terminus

Specifications

Our Abpromise guarantee covers the use of ab123479 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    One unit of protease hydrolyzes 1 picomole of Mouse renin FRET substrate 5-FAM/QXLTM 520 per minute at pH 7.5 at 25° C.
  • Applications

    Functional Studies

    SDS-PAGE

  • Form
    Liquid
  • Additional notes
    One unit of protease hydrolyzes 1 picomole of Mouse renin FRET substrate 5-FAM/QXLTM 520 per minute at pH 7.5 at 25° C.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituent: 0.6% Tris

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • Angiotensin forming enzyme
    • Angiotensinogenase
    • FLJ10761
    • HNFJ2
    • REN
    • Ren1
    • RENAA
    • RENI_HUMAN
    • Renin
    • Renin precursor renal
    • Renin-1
    • Renin-2
    see all
  • Function
    Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
  • Involvement in disease
    Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
    Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:613092]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.
  • Sequence similarities
    Belongs to the peptidase A1 family.
  • Cellular localization
    Secreted. Membrane. Associated to membranes via binding to ATP6AP2.
  • Information by UniProt

References

ab123479 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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