Recombinant mouse Prorenin protein (ab123479)

Overview

Description

  • NatureRecombinant
  • SourceHEK 293 cells
  • Amino Acid Sequence
    • AccessionP06281
    • SpeciesMouse
    • Molecular weight42 kDa including tags
    • Amino acids1 to 402
    • TagsHis tag C-Terminus

Specifications

Our Abpromise guarantee covers the use of ab123479 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityOne unit of protease hydrolyzes 1 picomole of Mouse renin FRET substrate 5-FAM/QXLTM 520 per minute at pH 7.5 at 25° C.
  • Applications

    Functional Studies

    SDS-PAGE

  • FormLiquid
  • Additional notes One unit of protease hydrolyzes 1 picomole of Mouse renin FRET substrate 5-FAM/QXLTM 520 per minute at pH 7.5 at 25° C.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituent: 0.6% Tris

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • Angiotensin forming enzyme
    • Angiotensinogenase
    • FLJ10761
    • HNFJ2
    • REN
    • Ren1
    • RENAA
    • RENI_HUMAN
    • Renin
    • Renin precursor renal
    • Renin-1
    • Renin-2
    see all
  • FunctionRenin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
  • Involvement in diseaseDefects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
    Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:613092]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.
  • Sequence similaritiesBelongs to the peptidase A1 family.
  • Cellular localizationSecreted. Membrane. Associated to membranes via binding to ATP6AP2.
  • Information by UniProt

References for Recombinant mouse Prorenin protein (ab123479)

ab123479 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab123479.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"