This product is an active protein and may elicit a biological response in vivo, handle with caution.
Non receptor tyrosine phosphatase 1
Protein phosphotyrosylphosphatase 1B
Protein tyrosine phosphatase 1B
Protein tyrosine phosphatase non receptor type 1
Protein tyrosine phosphatase placental
Protein-tyrosine phosphatase 1B
Tyrosine protein phosphatase non receptor type 1
Tyrosine-protein phosphatase non-receptor type 1
FunctionMay play an important role in CKII- and p60c-src-induced signal transduction cascades.
Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. Contains 1 tyrosine-protein phosphatase domain.
Post-translational modificationsOxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a 4-amino-3-isothiazolidinone serine cross-link, triggering a conformational change that inhibits substrate binding and activity. The active site can be restored by reduction.