The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ED50 < 5 ng/ml as determined in a cell proliferation assay using Human TF-1 erythroleukemia cells.
>95% by SDS-PAGE . ab170079 is purified by chromatography, sterile filtered and lyophilized.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -80°C.
Constituent: 100% PBS
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Add 0.5ml deionized water. Aliquot and freeze unused portion.
C mpl ligand
Megakaryocyte colony stimulating factor
Megakaryocyte colony-stimulating factor
Megakaryocyte growth and development factor
Megakaryocyte stimulating factor
Myeloproliferative leukemia virus oncogene ligand
Thrombopoietin nirs variant 1
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Involvement in disease
Defects in THPO are a cause of essential thrombocythemia (ET) [MIM:187950]. ET is inherited as an autosomal dominant trait which is characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications.
Belongs to the EPO/TPO family.
Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal.