The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Mouse TWEAK was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon reconsitution add a carrier protein (0.1% BSA). Store at -20°C long term. Avoid freeze / thaw cycle.
Reconstitute with sterile phosphate-buffered saline
containing at least 0.1% carrier protein.
APO 3 ligand
TNF-related weak inducer of apoptosis
Tumor necrosis factor (ligand) superfamily member 12
Tumor necrosis factor ligand superfamily member 12
Tumor necrosis factor superfamily member 12
Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines.
Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.
Belongs to the tumor necrosis factor family.
The soluble form derives from the membrane form by proteolytic processing.