Overview

Description

  • Nature
    Recombinant
  • Source
    Yeast
  • Amino Acid Sequence
    • Accession
    • Species
      Mouse
    • Sequence
      SAPKGRKARP RRAIAAHYEV HPRPGQDGAQ AGVDGTVSGW EETKINSSSP LRYDRQIGEF TVIRAGLYYL YCQVHFDEGK AVYLKLDLLV NGVLALRCLE EFSATAASSP GPQLRLCQVS GLLPLRPGSS LRIRTLPWAH LKAAPFLTYF GLFQVH
    • Molecular weight
      17 kDa
    • Amino acids
      94 to 249
    • Additional sequence information
      Amino acids 94 to 249 represent the chain for the secreted form of mouse TWEAK.

Specifications

Our Abpromise guarantee covers the use of ab184591 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    ELISA

    Western blot

  • Form
    Lyophilised
  • Additional notes

    Mouse TWEAK was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon reconsitution add a carrier protein (0.1% BSA). Store at -20°C long term. Avoid freeze / thaw cycle.

  • Reconstitution
    Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.

General Info

  • Alternative names
    • APO 3 ligand
    • APO 3L
    • APO3 ligand
    • APO3/DR3 ligand
    • APO3L
    • DR3LG
    • MGC129581
    • MGC20669
    • secreted form
    • TNF-related weak inducer of apoptosis
    • TNF12_HUMAN
    • TNFSF 12
    • Tnfsf12
    • TNFSF12 protein
    • Tumor necrosis factor (ligand) superfamily member 12
    • Tumor necrosis factor ligand superfamily member 12
    • Tumor necrosis factor superfamily member 12
    • TWEAK
    • UNQ181/PRO207
    see all
  • Function
    Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines.
  • Tissue specificity
    Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.
  • Sequence similarities
    Belongs to the tumor necrosis factor family.
  • Post-translational
    modifications
    The soluble form derives from the membrane form by proteolytic processing.
  • Cellular localization
    Secreted and Cell membrane.
  • Information by UniProt

References

ab184591 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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