Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli

Associated products

Specifications

Our Abpromise guarantee covers the use of ab9796 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity

    Determined by the dose-dependent stimulation of the proliferation of human TF-1 cells. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.

  • Applications

    Functional Studies

    SDS-PAGE

  • FormLyophilised
  • Additional notesThe ED50 was determined by its ability to stimulate chick E9 DRG neurite outgrowth. The ED50 is < 1.0 ng/ml, corresponding to a specific activity of > 1 x 106 units/mg.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    n/a

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • ReconstitutionPlease reconstitute this product in 200ul sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.

General Info

  • Alternative names
    • Beta nerve growth factor
    • Beta NGF
    • Beta-nerve growth factor
    • Beta-NGF
    • HSAN5
    • MGC161426
    • MGC161428
    • Nerve growth factor
    • Nerve growth factor (beta polypeptide)
    • Nerve growth factor beta
    • Nerve growth factor beta polypeptide
    • Nerve growth factor beta subunit
    • NGF
    • NGF_HUMAN
    • NGFB
    • NID67
    see all
  • FunctionNerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).
  • Involvement in diseaseNeuropathy, hereditary sensory and autonomic, 5
  • Sequence similaritiesBelongs to the NGF-beta family.
  • Cellular localizationSecreted.
  • Information by UniProt

References for Recombinant NGF protein (ab9796)

ab9796 has not yet been referenced specifically in any publications.

Product Wall

Ab9796 is a noncovalently disulfide-linked homodimer, of two 13.5kDa polypeptide monomers (238 total amino acid residues). The three disulfide bonds are required for biological activity.

As you have probably seen from the online datasheet, ab9796 -- NGF beta (human) recombinant protein -- is not currently in stock. The lead time for this item would be approx 7 working days. If you were to order 6 units on a single purchase order I coul...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"