Recombinant p15 Treponema pallidum protein (ab68120)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • Sequenceab68120 was purified by a proprietary chromatographic technique.

Specifications

Our Abpromise guarantee covers the use of ab68120 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityab68120 is immunoreactive with sera of Trp. Pallidum infected individuals.
  • Applications

    Western blot

    ELISA

  • Purity> 95 % SDS-PAGE.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 30% Glycerol, 0.2% Sarkosyl, 84mM Sodium chloride, 70mM Tris HCl, 14mM Glutathione, pH 8

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • 15 kDa lipoprotein
    • 15 kDa lipoprotein precursor (Major membrane immunogen)
    • Major membrane immunogen
    • tpp15
    • Treponema Pallidum Lipoprotein Immunogen p15
    see all
  • RelevanceThe 15 kDa lipoprotein of Treponema pallidum is a major immunogen during natural syphilis infection in humans and experimental infection in other hosts. The humoral and cellular immune responses to this molecule appear late in infection as resistance to reinfection is developing. The complete genome sequence of Treponema pallidum has been determined and shown to be 1,138,006 base pairs containing 1041 predicted coding sequences (open reading frames). Systems for DNA replication, transcription, translation, and repair are intact, but catabolic and biosynthetic activities are minimized. Treponema pallidum is a gram-negative spirochaete bacterium and there are at least four known subspecies: T. pallidum pallidum, which causes syphilis; T. pallidum pertenue, which causes yaws; T. pallidum carateum, which causes pinta; and T. pallidum endemicum, which causes bejel. There is no vaccine for syphilis. The outer membrane of T. pallidum has too few surface proteins for an antibody to be effective. Efforts to develop a safe and effective syphilis vaccine have been hindered by uncertainty about the relative importance of humoral and cellular mechanisms to protective immunity and the fact that T. pallidum outer membrane proteins have not been unambiguously identified.
  • Cellular localizationBacterial cell membrane; lipid-anchor (Probable).

References for Recombinant p15 Treponema pallidum protein (ab68120)

ab68120 has not yet been referenced specifically in any publications.

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