Recombinant p17 Treponema pallidum protein (ab68122)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab68122 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityab68122 is immunoreactive with sera of Treponema Pallidum infected individuals.
  • Applications

    Western blot

    ELISA

  • Purity> 90 % SDS-PAGE.
    ab68122 was purified by a proprietary chromatographic technique.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 8M Urea, 10mM Tris HCl, 1mM EDTA, 1mM DTT, pH 8

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • tpp17
    • tpp17 protein
    • Treponema Pallidum Lipoprotein p17
  • Relevancep17 is a 17-kDa major membrane lipoprotein of Treponema pallidum. The complete genome sequence of Treponema pallidum has been determined and shown to be 1,138,006 base pairs containing 1041 predicted coding sequences (open reading frames). Systems for DNA replication, transcription, translation, and repair are intact, but catabolic and biosynthetic activities are minimized. Treponema pallidum is a gram-negative spirochaete bacterium and there are at least four known subspecies: T. pallidum pallidum, which causes syphilis; T. pallidum pertenue, which causes yaws; T. pallidum carateum, which causes pinta; and T. pallidum endemicum, which causes bejel. There is no vaccine for syphilis. The outer membrane of T. pallidum has too few surface proteins for an antibody to be effective. Efforts to develop a safe and effective syphilis vaccine have been hindered by uncertainty about the relative importance of humoral and cellular mechanisms to protective immunity and the fact that T. pallidum outer membrane proteins have not been unambiguously identified.
  • Cellular localizationBacterial cell membrane; lipid-anchor (Probable).

References for Recombinant p17 Treponema pallidum protein (ab68122)

ab68122 has not yet been referenced specifically in any publications.

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