The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityThe biological activity of ab87689 was determined in a chemotaxis assay using a Boyden chamber with swine PBMC activated with PHA for 3 days followed by IL2. Bioactivity is typically detected at 10 ng/mL.
% SDS-PAGE. ab87689 is purified by Ion-exchange chromatography.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionReconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.
Reconstituted protein is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.
C-X-C motif chemokine 11
Chemokine (C-X-C motif) ligand 11
Chemokine C-X-C motif ligand 11
Interferon gamma inducible protein 9
Interferon gamma-inducible protein 9
Interferon inducible T cell alpha chemoattractant
Interferon-inducible T-cell a chemoattractant I-TAC
Interferon-inducible T-cell alpha chemoattractant
Small inducible cytokine B11
Small inducible cytokine subfamily B (Cys-X-Cys) member 11
Small inducible cytokine subfamily B (Cys-X-Cys) member 9B
Small inducible cytokine subfamily B, member 11
Small inducible cytokine subfamily B, member 9B
Small-inducible cytokine B11
FunctionChemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.
Tissue specificityHigh levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.
Sequence similaritiesBelongs to the intercrine alpha (chemokine CxC) family.