ReconstitutionReconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.
Beta thromboglobulin like protein
C-X-C motif chemokine 8
chemokine, CXC motif, ligand 8
GCP/IL-8 protein I
GCP/IL-8 protein II
GCP/IL-8 protein III
GCP/IL-8 protein IV
GCP/IL-8 protein V
GCP/IL-8 protein VI
Granulocyte chemotactic protein 1
IL8/NAP1 form I
IL8/NAP1 form II
IL8/NAP1 form III
IL8/NAP1 form IV
IL8/NAP1 form V
IL8/NAP1 form VI
Lymphocyte-derived neutrophil-activating factor
Monocyte-derived neutrophil chemotactic factor
Monocyte-derived neutrophil-activating peptide
Neutrophil activating peptide 1
Neutrophil activating protein 1
Neutrophil-activating protein 1
Protein 3 10C
Small inducible cytokine subfamily B member 8
T cell chemotactic factor
T-cell chemotactic factor
FunctionIL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.
Sequence similaritiesBelongs to the intercrine alpha (chemokine CxC) family.
Post-translational modificationsSeveral N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form.