The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityThe biological activity of ab87908 was determined in a chemotaxis assay using a Boyden chamber with freshly isolated swine PBMC monocytes using a Percoll gradient enrichment method. Biological activity typically peaks at 100 ng/mL.
% by SDS-PAGE. ab87908 was purified using Ion-exchange chromatography
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionReconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.
Reconstituted protein is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C.
C C motif chemokine 3 like 1
Chemokine (C C motif) ligand 3 like 1
Chemokine (C C motif) ligand 3 like 3
Chemokine (C C motif) ligand 3 like, centromeric
chemokine (CC motif) ligand 3 like 1
G0/G1 switch regulatory protein 19-2
Small inducible cytokine A3 like 1 precursor
Small-inducible cytokine A3-like 1
Tonsillar lymphocyte LD78 beta
Tonsillar lymphocyte LD78 beta protein
FunctionChemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.
Sequence similaritiesBelongs to the intercrine beta (chemokine CC) family.
Post-translational modificationsThe N-terminal processed forms LD78-beta(3-70) and LD78-beta(5-70) are produced by proteolytic cleavage after secretion from peripheral blood monocytes. The cleavage to yield LD78-beta(3-70) is probably achieved by DPP4.