Overview

  • Product nameRecombinant rat CHM protein
  • Protein lengthFull length protein

Description

  • NatureRecombinant
  • SourceSpodoptera frugiperda
  • Amino Acid Sequence
    • SpeciesRat

Specifications

Our Abpromise guarantee covers the use of ab91070 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityActivity: 1 pmol of CHM will mediate transfer of 2 pmol of geranylgeraniol by RabGGTase onto 1 pmol of Rab7 in 3 minutes.
  • Applications

    Functional Studies

    SDS-PAGE

  • Purity> 90 % SDS-PAGE.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 5mM DTT, 40mM Sodium chloride, 25mM HEPES, pH 7.2

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • CHM
    • Chm
    • Choroideraemia protein
    • Choroideremia
    • DXS540
    • FLJ38564
    • GGTA
    • HSD 32
    • MGC102710
    • Rab escort protein 1
    • Rab geranylgeranyltransferase component A
    • Rab proteins geranylgeranyltransferase component A 1
    • RAE1_HUMAN
    • REP 1
    • REP-1
    • REP1
    • TCD
    • TCD protein
    see all
  • FunctionBinds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Also a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation.
  • Involvement in diseaseDefects in CHM are the cause of choroideremia (CHM) [MIM:303100]. An X-linked recessive disease characterized by a slowly progressive degeneration of the choroid, photoreceptors, and retinal pigment epithelium. Affected males develop night blindness in their teenage years followed by loss of peripheral vision and complete blindness at middle age. Carrier females are generally asymptomatic but funduscopic examination often shows patchy areas of chorioretinal atrophy.
  • Sequence similaritiesBelongs to the Rab GDI family.
  • Information by UniProt

References for Recombinant rat CHM protein (ab91070)

ab91070 has not yet been referenced specifically in any publications.

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