This product is an active protein and may elicit a biological response in vivo, handle with caution.
DNA directed DNA polymerase beta
DNA pol beta
DNA polymerase beta
DNA polymerase beta subunit
Polymerase (DNA directed) beta
FunctionRepair polymerase. Conducts "gap-filling" DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
Sequence similaritiesBelongs to the DNA polymerase type-X family.
DomainResidues 239-252 form a flexible loop which appears to affect the polymerase fidelity.
Post-translational modificationsMethylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity.