Recombinant rat FNTA + FNTB protein (ab90512)

Overview

  • Product nameRecombinant rat FNTA + FNTB protein
  • Protein lengthFull length protein

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesRat
    • TagsGST tag N-Terminus

Associated products

Specifications

Our Abpromise guarantee covers the use of ab90512 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityActivity: 1 pmol of FNTA + FNTB will transfer 1 pmol of farnesyl to H-Ras in 15 min at 37°C.
  • Applications

    Functional Studies

    SDS-PAGE

  • Purity> 90 % SDS-PAGE.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 5mM DTT, 100mM Sodium chloride, 100mM HEPES, pH 7.2

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • 2010013E13Rik
    • AA409500
    • CAAX box, alpha
    • CAAX farnesyltransferase subunit alpha
    • CAAX farnesyltransferase subunit beta
    • Farnesyltransferase
    • Farnesyltransferase, CAAX box, beta
    • Farnesyltransferase, subunit alpha
    • FNTB
    • FPTA
    • FPTB
    • FTA
    • FTase beta
    • FTase-alpha
    • GGTase-I-alpha
    • MGC105303
    • MGC31935
    • MGC99680
    • PFAS
    • PGGT1A
    • Protein farnesyltransferase subunit beta
    • Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
    • PTAR2
    • RAS proteins prenyltransferase beta
    • Ras proteins prenyltransferase subunit alpha
    • type I protein geranyl-geranyltransferase subunit alpha
    see all
  • RelevanceFNTA, also known as CAAX farnesyltransferase (FTase), attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the so-called CAAX box, where C is cysteine, A is usually but not always an aliphatic amino acid, and X is typically methionine or serine. This type of posttranslational modification provides a mechanism for membrane localization of proteins that lack a transmembrane domain. This enzyme has the remarkable property of farnesylating peptides as short as four residues in length that conform to the CAAX consensus sequence. FNTB, farnesyltransferase subunit beta, catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.

References for Recombinant rat FNTA + FNTB protein (ab90512)

ab90512 has not yet been referenced specifically in any publications.

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