Recombinant rat Geranyl-Geranyl-Transferase protein (ab90114)

Overview

  • Product name
    Recombinant rat Geranyl-Geranyl-Transferase protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Rat

Specifications

Our Abpromise guarantee covers the use of ab90114 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Activity: 1 pmol of GGTase-I will transfer 5 pmol of Farnesyl to RhoA in 15 min at 37°C.
  • Applications

    Functional Studies

    SDS-PAGE

  • Purity
    > 90 % SDS-PAGE.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 5mM DTT, 25mM Sodium chloride, 25mM HEPES, pH 7.2

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • 602031
    • BGGI
    • CAAX farnesyltransferase alpha subunit
    • EC 2.5.1.58
    • EC 2.5.1.59
    • Farnesyltransferase alpha subunit
    • Farnesyltransferase CAAX box alpha
    • FPTA
    • FTase alpha
    • Geranylgeranyl transferase type I subunit beta
    • Geranylgeranyltransferase type I beta subunit
    • GGTase I alpha
    • GGTase-I-beta
    • GGTI
    • MGC99680
    • PGGT1A
    • Pggt1b
    • Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit
    • Protein geranylgeranyltransferase type I, beta subunit
    • PTAR2
    • Ras proteins prenyltransferase alpha
    • Type I protein geranyl geranyltransferase alpha subunit
    see all
  • Relevance
    Geranyl-Geranyl-Transferase catalyzes the transfer of the farnesyl and geranylgeranyl groups from farnesyl and geranylgeranyl-diphosphate to proteins containing a C-terminal CaaX motif, where ’C’ is a conserved cysteine that is the site of farnesyl modification, ’a’ is usually an aliphatic amino acid, and ’X’ is leucine or phenylalanine. Farnesyltransferase (FT) and GGTase-I are closely related, sharing a common a subunit and 30% identity in their ß subunits.

References

ab90114 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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