Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesRat

Specifications

Our Abpromise guarantee covers the use of ab91602 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityATPase Activity Assay: Positive
  • Applications

    Western blot

    Functional Studies

    SDS-PAGE

  • Purity> 90 % SDS-PAGE.
    Purified by Multi-step chromatography. >90% pure as determined by SDS-PAGE and Western blot analyses. This protein does not contain DnaK as demonstrated by western blot analysis using anti-DnaK.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50mM Tris HCl, 100mM Sodium chloride, 1mM DTT, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • DnaK type molecular chaperone HSP70 1
    • Epididymis secretory protein Li 103
    • FLJ54303
    • FLJ54370
    • FLJ54392
    • FLJ54408
    • FLJ75127
    • Heat shock 70 kDa protein 1
    • Heat shock 70 kDa protein 1/2
    • Heat shock 70 kDa protein 1A/1B
    • Heat shock 70kDa protein 1A
    • Heat shock 70kDa protein 1B
    • Heat shock induced protein
    • HEL S 103
    • HSP70 1
    • HSP70 1B
    • HSP70 2
    • HSP70-1/HSP70-2
    • HSP70-1A
    • HSP70.1
    • HSP70.1/HSP70.2
    • HSP70I
    • HSP71_HUMAN
    • HSP72
    • HSPA1
    • HSPA1A
    • HSPA1B
    see all
  • FunctionIn cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.
  • Tissue specificityHSPA1B is testis-specific.
  • Sequence similaritiesBelongs to the heat shock protein 70 family.
  • Cellular localizationCytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
  • Information by UniProt

Recombinant rat Hsp70 protein images

  • SDS-PAGE Analysis of 0.5 µg ab91602
  • All lanes : Anti-Hsp70 Monoclonal Antibody at 1 µg/ml

    Lane 1 : Molecular weight markers
    Lane 2 : ab91602 at 0.1 µg

References for Recombinant rat Hsp70 protein (ab91602)

ab91602 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"