The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityBiological Activity:
ab78597 is fully biologically active when compared to standards via dose-dependent induction of IL6 production in cultured mouse NIH 3T3 fibrolasts. The ED50 for ab78597 in this assay was 30ng/ml.
% SDS-PAGE. Purity is greater than 97% as determined by reducing and non-reducing SDS-PAGE.
Endotoxin level is <0.01ng/ug or <0.1EU/ug.
This product is filter sterilised.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionReconstitute with sterile water at a concentration of 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Reconstituted material should be aliquoted and frozen at -20C. It is recommended to add a carrier protein (0.1% HSA or BSA) for long term storage.
Cytotoxic T lymphocyte associated antigen 8
Cytotoxic T lymphocyte associated protein 8
Cytotoxic T lymphocyte associated serine esterase 8
Cytotoxic T-lymphocyte-associated antigen 8
Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8)
FunctionLigand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).
Tissue specificityRestricted to activated memory T-cells.
Sequence similaritiesBelongs to the IL-17 family.
Post-translational modificationsFound both in glycosylated and nonglycosylated forms.