The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityab119722 is fully bioactive when compared to a known standard. The ED50 as determined by the dose-dependant induction of IL-6 in NHDF is 1.94 ng/ml
% SDS-PAGE. Purity: > 98% by SDS-PAGE and RP-HPLC analysis.
Endotoxin level is < 0.01 ng per µg of IL17F.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -80°C. Avoid freeze / thaw cycle. For long term storage it is recommended to add a carrier protein on reconstitution (0.1% HSA or BSA).
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionCentrifuge the vial prior to opening. Reconstitute in sterile water to a concentration of 0.1 mg/ml. The solution can then be diluted into other aqueous buffers.
Cytokine ML 1
Mutant IL 17F
FunctionLigand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation.
Tissue specificityExpressed in activated, but not resting, CD4+ T-cells and activated monocytes.