The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Specific Activity of 6.6 x 105 IU/mg.
% SDS-PAGE. IL4 was purified by proprietary chromatographic techniques.
Purity: Greater than 98.0% as determined by analysis by RP-HPLC and analysis by SDS-PAGE.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Reconstitute the lyophilized IL4 in sterile 18Mohm/cm water to not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
B cell growth factor 1
B cell IgG differentiation factor
B Cell Stimulatory Factor 1
B-cell stimulatory factor 1
IGG1 induction factor
Interleukin 4 variant 2
Interleukin 4, isoform 1
Lymphocyte stimulatory factor 1
Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
Involvement in disease
Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.