This product is an active protein and may elicit a biological response in vivo, handle with caution.
Homolog of mouse T cell itk/tsk
IL 2 inducible T cell kinase
IL2 inducible T cell kinase
Interleukin 2 inducible T cell kinase
T cell specific kinase
Tyrosine protein kinase
Tyrosine protein kinase ITK/TSK
Tyrosine protein kinase Lyk
Tyrosine-protein kinase ITK/TSK
Tyrosine-protein kinase Lyk
Plays a role in T-cell proliferation and differentiation.
T-cell lines and natural killer cell lines.
Involvement in disease
Defects in ITK are the cause of lymphoproliferative syndrome EBV-associated autosomal type 1 (LPSA1) [MIM:613011]. LPSA1 is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Inadequate immune response to EBV can have a fatal outcome. Clinical features include splenomegaly, lymphadenopathy, anemia, thrombocytopenia, pancytopenia, recurrent infections. There is an increased risk for lymphoma.
Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. Contains 1 Btk-type zinc finger. Contains 1 PH domain. Contains 1 protein kinase domain. Contains 1 SH2 domain. Contains 1 SH3 domain.
Cell membrane. Localizes to cell surface receptors in the plasma membrane after stimulation with respective receptors (TCR, CD28, CD2) in T-cells.
SDS-PAGE - Active rat ITK protein fragment (ab196125)
10% SDS-PAGE analysis of ab196125 with Coomassie staining.
Lane 1: 20 µg Active rat ITK protein fragment (ab196125) Lane 2: Protein marker
Functional Studies - Active rat ITK protein fragment (ab196125)
Enzyme reaction was conducted at 30°C for 1 hour with 2 μM Tyr peptide in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. After the 1 hour incubation, diluted development reagent was added. Percentage phosphorylation was calculated based on the emission ratio of 445/520 nm after excitation.
has not yet been referenced specifically in any publications.
Publishing research using ab196125? Please let us know so that we can cite the reference in this datasheet.
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