The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.
Constituents: 10% Glycerol
70 kDa lamin
LA delta 50
Lamin A delta 50
renal carcinoma antigen NYREN32
RelevanceProgerin is a 614 amino acid protein involved in Hutchinson-Gilford progeria syndrome. Progerin is most often generated by a point mutation (C1824T) in the LMNA gene that codes for lamin A and C. This mutation activates a cryptic splice site and gives rise to a form of lamin A with a 50-amino acids internal deletion within the carboxyl-terminal domain of the protein. Approximately 80% of Hutchinson-Gilford progeria syndrome cases carry a single copy of the most common mutation, a silent point mutation, G608G (GGC > GGT), within exon 11 of LMNA gene.
Cellular localizationCell Membrane, Cytoplasmic, intermediate filament and Nuclear
Recombinant Rat Progerin protein images
SDS-PAGE - Progerin protein (Rat) (ab93917)
ab93917 by SDS-PAGE (8% polyacrylamide) and stained with Coomassie Blue.
Lane 1: MWM
Lane 2: 4µg ab93917
Lane 3: 3µg ab93917
Lane 4: 2µg ab93917
Lane 5: 1µg ab93917
References for Recombinant Rat Progerin protein (ab93917)
has not yet been referenced specifically in any publications.
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